CFTR F508del · the story in 9 steps

What goes wrong in the most common form of cystic fibrosis Open the detailed explorer →
Loading the 3D model...
Step 1 of 9 · The gate
⚠ ILLUSTRATION (Artistic schematic · not an MD simulation)
Building block 440
📷 Camera Inspector
Step:1. The gate
Target [X,Y,Z]:[0, 0, 0]
Distance:0
Lens FOV:20
Orbit, zoom, or pan the 3D model, then copy:
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Shrunk to atom size: each ball is a single atom
Building block 508 (Phe508) The folding piece (NBD1) Loop from the other half (ICL4) Normal position (faint) Empty pocket (where 508 belongs) Rest of the gate
Explore sequence (fisheye near 508):
Building block 508
Phe508 · missing in cystic fibrosis